Spatially Controlled Surface Immobilization of Non-Modified Peptides

  • chair:

    Pauloehrl, T. / Welle, A. / Bruns, M. / Linkert, K. / Börner, H. / Bastmeyer, M. / Delaittre, G. / Barner-Kowollik, C. (2013)
  • place:

    Angewandte Chemie International Edition 37 (2013), 52, 9714–9718
  • Date: 2013

  • Pauloehrl, T. / Welle, A. / Bruns, M. / Linkert, K. / Börner, H. / Bastmeyer, M. / Delaittre, G. / Barner-Kowollik, C. (2013): „Spatially Controlled Surface Immobilization of Non-Modified Peptides“. In: Angewandte Chemie International Edition 37 (2013), 52, 9714–9718

Abstract

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A phencyclone derivative is used to achieve light-controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels–Alder reaction and can undergo light-triggered ring-opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time-of-flight secondary-ion mass spectrometry (ToF-SIMS).