Bolat, S. / Greifenstein, R. / Franzreb, M. / Holtmann, D. (2023)

Physical Sciences Reviews, 2023. https://doi.org/10.1515/psr-2022-0110

Abstract

The application potential of enzymes is undoubtedly very high. However, despite the very large number of different enzymes and enzyme activities, the number of industrial enzyme processes is comparatively small. The particular challenge often lies in transferring promising laboratory processes to an industrial scale. Here, the required performance parameters, such as enzyme stability or productivity, must be achieved. On the one hand, this can be achieved by improving the enzymes. On the other hand, the key performance indicators can often only be achieved by using technical systems in the sense of process intensification. In enzymatic processes, immobilization of enzymes is often the means of choice to enable technical processes. The aim of this article is to outline the most important enzyme immobilization methods and to summarize the most important performance indicators of immobilized enzymes. Finally, the different immobilization methods and performance indicators are compared in a case study with unspecific peroxygenase.

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