Lucas Warmuth, L. / Weiß, A. / Reinhardt, M. / Meschkov, A. / Schepers, U. / Podlech, L. (2021)

Beilstein J. Org. Chem. 2021, 17, 224–228. https://doi.org/10.3762/bjoc.17.22

Abstract

The total synthesis of decarboxyaltenusin (5’-methoxy-6-methyl-[1,1’-biphenyl]-3,3’,4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps. The key reaction was a palladium-catalyzed Suzuki coupling of an aromatic boronate with a brominated resorcin derivative.

 Download