The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
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chair:
Gröschel , M. I. / Meehan, C. J. / Barilar, I. / Diricks, M. / Gonzaga, A / Steglich, M. / Conchillo-Solé, O. / Scherer, I.-C. / Mamat, U. / Luz, C.F. / De Bruyne, K. / Utpatel, C. / Yero, D. / Gibert, I. / Daura, X. / Kampmeier, S. / Rahman, N. A. / Kresken, M. / van der Werf, T. S. / Alio, I. / Streit, W. R. / Zhou, K. / Schwartz, T. / Rossen, J. W. A. / Farhat, M. R. / Schaible, U. E. / Nübel, U. / Rupp, J. / Steinmann, J. / Niemann, S. / Kohl, T. A. (2020)
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place:
NATURE COMMUNICATIONS, 2020, doi.org/10.1038/s41467-020-15123-0
- Date: April 2020
Abstract
Recent studies portend a rising global spread and adaptation of human- or healthcareassociated
pathogens. Here, we analyse an international collection of the emerging, multidrug-
resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to
infer population structure and clonality at a global level. We show that the S. maltophilia
complex is divided into 23 monophyletic lineages, most of which harbour strains of all
degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated
strains, linked to key virulence and resistance genes. Transmission analysis identifies
potential outbreak events of genetically closely related strains isolated within days or weeks
in the same hospitals.
