Direct UV-Induced Functionalization of Surface Hydroxy Groups by Thiol-Ol Chemistry

  • chair:

    Li, L. / Li, J. / Du, X. / Welle, A. / Grunze, M. / Trapp, O. / Levkin, P. (2014)
  • place:

    Angew. Chem. Int. Ed. 53 (2014), 15, 3835-3839
  • Date: 2014

  • Li, L. / Li, J. / Du, X. / Welle, A. / Grunze, M. / Trapp, O. / Levkin, P. (2014): „Direct UV-Induced Functionalization of Surface Hydroxy Groups by Thiol-Ol Chemistry“. In: Angew. Chem. Int. Ed. 53 (2014), 15, 3835-3839

Abstract

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A novel UV-initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol-containing molecules (termed “thiol–ol” modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups.

We demonstrate that different thiol-containing molecules, such as fluorophores, thiol-terminated poly(ethylene glycol) (PEG-SH), and a cysteine-containing peptide, can be attached onto the surface of porous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate). Direct functionalization of other hydroxy-group-bearing surfaces, fabrication of micropatterns, and double patterning have been also demonstrated using the thiol–ol method.