Short Cationic Antimicrobial Peptides Interact with ATP

  • chair:

    Hilpert, K. / McLeod, B. / Yu, J. / Elliott, M. / Rautenbach, M. / Ruden, S. / Bürck, J. / Muhle-Goll, C. / Ulrich, A. / Keller, S. / Hancock, R. (2010)
  • place:

    Antimicrobial Agents and Chemotherapy 54 (2010), 10, 4480-4483
  • Date: 2010

  • Hilpert, K. / McLeod, B. / Yu, J. / Elliott, M. / Rautenbach, M. / Ruden, S. / Bürck, J. / Muhle-Goll, C. / Ulrich, A. / Keller, S. / Hancock, R. (2010):„Short Cationic Antimicrobial Peptides Interact with ATP“. In: Antimicrobial Agents and Chemotherapy 54 (2010), 10, 4480-4483

Abstract

The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. a-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.

 

 

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