Development of a photothermal double beam laser scanning system in biopharmaceutrical applications

  • chair:

    Faubel, W. / Gotter, B. / Heißler, S. / Schlegel, M. / Neubert, R. (2010)
  • place:

    Journal of Physics: Conference Series 214 (2010), 012062
  • Date: 2010

  • Faubel, W. / Gotter, B. / Heißler, S. / Schlegel, M. / Neubert, R. (2010): „Development of a photothermal double beam laser scanning system in biopharmaceutrical applications“. In: Journal of Physics: Conference Series 214 (2010), 012062

Abstract

Photothermal beam deflection (PDS) has been applied to obtain information regarding the penetration of methylorange (MO) and ditranol (DI) into artificial membranes. The measurable depth range is 56 μm. Photothermal beam deflection allows on the one hand depth resolved investigations by the use of a frequency modulation of the excitation beam to reach deeper regions even in opaque sample, and on the other hand lateral imaging. To explore the potential use of a novel photothermal double beam laser scanning system, measurements in drug delivery analysis have been used for depth profiling and imaging into an artificial membrane, which represents stratum corneum or bovine hoof, appropriately.

 

 

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